In RA patients undergoing anti-TNF infliximab therapy because of severe disease, high-grade inflammation was independently and negatively correlated with circulating adiponectin concentrations, whereas low adiponectin levels clustered with metabolic syndrome features such as dyslipidemia and high plasma glucose levels that have been reported to contribute to atherogenesis in RA [116]. This evidence concerns the gene ADIPOQ and rheumatoid arthritis.