According to the data in the literature, the number of AgNORs has been proven to be a prognostic factor for malignant neoplasms of different locations: in Cox multivariate analysis, the number of nucleolar organizer regions and the histological type were the main prognostic factors predicting the outcome in laryngeal cancer, and their prognostic value was higher than that of Ki-67 expression [50]. This evidence concerns the gene MKI67 and laryngeal carcinoma.