Among the 22 genes, the transcription factor TCF4 (T-cell factor 4) was shown to be a part of a gene set overexpressed in leukemic cells of acute T-cell leukemia/lymphoma patients [13] and to be associated with chemotherapy cross-resistance and treatment outcome in childhood acute lymphoblastic leukemia [14]. The gene discussed is TCF7L2; the disease is acute lymphoblastic leukemia.