IRF5 and systemic lupus erythematosus: Three functional variants of IRF5 that are associated with SLE risk have been touted to define the risk to develop SLE: including a splice site, a 30 base pair in-frame insertion/deletion, and an alternative polyadenylation site in the 3’UTR region[22]; however, no fine mapping study has been reported to establish whether these, over the many other variants, including an interesting promoter variant[23] are preferred as explanations for SLE risk.