Since previous publications have shown that female carriers of MECP2 duplications had psychiatric symptoms, the mother of the patients (P01D) completed a Symptom Checklist-90 [40,41], and both parents completed the Wechsler Adult Intelligence Scale-Revised [42,43] and the Broad Autism Phenotype Questionnaire (BAPQ) [44]. The gene discussed is MECP2; the disease is autism.