We were able to demonstrate a down-regulation of TLR2 mRNA expression after treating IL-1β prestimulated IVD cells with curcumin, which confirms findings in other cell types such as monocytic THP-1 cells, HL-60 promyelocytic leukemia cells and primary peripheral blood polymorphonuclear neutrophils[38]. The gene discussed is TLR2; the disease is acute promyelocytic leukemia.