Therefore, in the absence of unequivocal staining with an anti-LC antibody, additional immunofluorescence and immunohistochemistry studies should be performed to verify the absence of staining with antibodies specific for amyloid precursors found in hereditary amyloidosis (i.e. lysozyme, apolipoprotein A1, apoliprotein A2, fibrinogen, gelsolin and transthyretin). This evidence concerns the gene TTR and hereditary amyloidosis.