BTK and B-cell chronic lymphocytic leukemia: Briefly, this Btk inhibitor induced apoptosis in B-CLL but not in normal cells (Herman et al., 2011) and reversed the microenvironment-induced survival (Herman et al., 2011), signaling (Herman et al., 2011; de Rooij et al., 2012), adhesion (de Rooij et al., 2012), and migration (Herman et al., 2011; Ponader et al., 2012).