AKT1 and B-cell chronic lymphocytic leukemia: Enhanced basal and stimulated Akt phosphorylation is observed in a subset of CLL patients, with increased phosphorylation associated with progressive disease (Barragan et al., 2006; Longo et al., 2007) and decreased phosphorylation associated with an “anergic” phenotype (Muzio et al., 2008).