The adaptor p66Shc, which can inhibit Akt phosphorylation and promote apoptotic signaling via the BCR (Pacini et al., 2004), was profoundly impaired in B-CLL compared to normal B cells, with lower expression in the unfavorable prognosis group (Capitani et al., 2010). Here, AKT1 is linked to B-cell chronic lymphocytic leukemia.