AKT1 and B-cell chronic lymphocytic leukemia: Moreover, PI3K multi-target inhibitors were found to inhibit B-CLL migration toward stromal cells via CXCL12, as well as inhibit Akt and S6 phosphorylation more efficiently than specific p110δ (IC87114) and p110β/δ (TGX115) inhibitors (Niedermeier et al., 2009).