AKT1 and B-cell chronic lymphocytic leukemia: In vitro, CAL-101 reduced B-CLL survival, associated with inhibition of Akt (Herman et al., 2010; Hoellenriegel et al., 2011) and ERK (Hoellenriegel et al., 2011) pathways, more efficiently than LY294002 (Herman et al., 2010).