While several reports refer to the impact of neuroinflammation in the adult neurogenesis niches, as in multiple sclerosis, Alzheimer's disease and brain injury (Tepavčević, 2011; Wood et al., 2011; L'Episcopo et al., 2012) (Hamilton and Holscher, 2012), the more subtle effects of inflammation-induced alterations in the CP per se, and its impact in the adult SVZ, are presently unknown. This evidence concerns the gene CP and early-onset autosomal dominant Alzheimer disease.