At 12 h after reperfusion, plasma levels of HMGB1, a mediator of endotoxic shock and sepsis, were significantly lower in the fish oil group (0.763 ± 0.32 ng/ml) than in the lipid-free group (1.4 ± 0.63 ng/ml, P = 0.0398) (Fig. 5). This evidence concerns the gene HMGB1 and Sepsis.