XDH and hyperuricemia: One such consequence is induction of hyperuricemia due to increased xanthine oxidase activity, increased cell death/turnover, alteration of cellular macromolecules making them more amenable to urate crystallization (a mechanism akin to the role of oxidized lipoproteins contributing to atherosclerotic plaques) or impairment in renal urate excretion (increased lactate production, increased urate reabsorption because of hypoxic signal to kidney) [17].