The profile of patients with nonalbuminuric renal impairment was different from those with albuminuria; there was a higher proportion of women in patients with nonalbuminuric renal impairment, and these patients were older, had a higher prevalence of obesity, had better metabolic control with less use of insulin, were less likely to smoke and had a lower prevalence of macrovascular disease. The gene discussed is INS; the disease is Obesity.