Recently, Foxp3- CD4+CD25+CD127- iTreg with appreciable suppressive activity on effector T cell proliferation, although less than that displayed by Treg cells from healthy controls, were demonstrated in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome [19]. The gene discussed is FOXP3; the disease is Abnormal intestine morphology.