In contrast to the significant reduction of CD4+ T cells during acute phase of infection (Figure 1), the distribution of CD4+ T cell subsets in healthy controls and scrub typhus patients were generally consistent, with the exception of CM (%, 21.7±12.6 in acute phase versus 28.0±6.8 in healthy controls) and CCR7−CD45RA+ (21.3±13.1 versus 9.1±5.8) (Figure 5A and B). Here, CD4 is linked to scrub typhus.