FOXP3 and scrub typhus: Interestingly, both CD4+CD25++ and CD4+Foxp3+ T cells were significantly reduced in scrub typhus patients (CD4+CD25++, %, 0.191±0.194 in acute phase and 0.256±0.22 in convalescent phase; CD4+Foxp3+, 0.363±0.361 in acute phase and 0.683±0.480 in convalescent phase) when compared with healthy controls (CD4+CD25++, 1.096±0.250; CD4+Foxp3+, 1.844±0.451) (Figure 4A and B).