PCMT1 and Seizure: A critical need for PIMT action in the brain is evident by its high specific activity in this tissue [18], [21] as well as the overt neurological phenotype of PIMT KO mice: increased brain size, abnormal neuro-anatomical and electrophysiological properties of hippocampal cells, atypical behavior, and fatal epileptic seizures beginning at 4 weeks of age [18], [19], [22]–[24].