We also searched for TET2, DNMT3A, ASXL1, EZH2, IDH1/2 and CBL gene families mutations, given their potential clinical importance in diseases closely associated with SM like primary myelofibrosis, chronic myelomonocytic leukemia (CMML) and others [11]–[17]. This evidence concerns the gene DNMT3A and systemic mastocytosis.