PDK1 and familial pancreatic carcinoma: Additionally, miR-196a and miR-210 have been shown to play an oncogenic role by targeting several tumor suppressor genes (ANXA1, KRT5, RAD52) affecting proliferation and hypoxic stress [39]–[42], while miR-375 and -216a, which are frequently downregulated in pancreatic cancer, have been implicated in insulin secretion and in regulation of cell survival and proliferation by targeting several oncogenes such as PDK1, JAK2, ATG7 [25], [43]–[46].