Third, haplotype association analysis is the most powerful method to explore the intrinsic effects of gene, but most of the literatures identified in our present meta-analysis were focused on the relation between the two TGFBR1 SNPs and tumor susceptibility, which made it difficult to investigate the TGFBR1 haplotype effects on carcinogenesis. This evidence concerns the gene TGFBR1 and neoplasm.