GPT and chronic hepatitis B virus infection: In the natural history of chronic hepatitis B (CHB), hepatitis B e antigen (HBeAg) expression has been used clinically as an indicator of active HBV replication, and seroconversion from HBeAg to its antibody, anti-HBe, is usually characterized by a decrease in HBV replication, normalization of serum alanine aminotransferases (ALT) levels and remission of liver disease, which correspond to the so called “inactive HBV carrier state” [10].