Although other researchers reported the anti-fibrosis role of CXCL9, we further demonstrated that CXCL9 and CXCL10, but not CXCL11 or CXCL4 could decreased the gene expression of the collagen on HSCs line LX-2 activated by TGF-β, which was considered as an important pro-fibrosis mediator in schistosomiasis. The gene discussed is CXCL11; the disease is schistosomiasis.