After bio-function analysis, we focused on two chemokines CXCL9 and CXCL10, and showed that both of them can inhibit the expression of collagen in human HSCs line LX-2, liver non-parenchymal cells, and primary HSCs of schistosomiasis mice indicating the anti-fibrosis property. This evidence concerns the gene CXCL9 and schistosomiasis.