In contrast, several known driver factors that are frequently mutated in CRC, including MINT3 [32], [33], MSH2 [34] and MSH6 [9], showed no change in expression in this study, suggesting that the genetic heterogeneity of CRC or the mutated products might be deleterious even if the expression level is unaffected. The gene discussed is MSH2; the disease is colorectal carcinoma.