We checked the expression of the slicing factors derived from NCBI and SpliceAid 2 (http://www.introni.it/spliceaid.html), and found that four splicing factors, including RBFOX1, SPRK1, MBNL1 and SRRM2, were significantly dysregulated between the cancer tissue and non-cancer tissue (Table S1), suggesting that the anomalous splicing activity in cancer tissue might be related with the dysregulation of the splicing factors. This evidence concerns the gene SRRM2 and cancer.