NOTCH2 and colorectal carcinoma: Because the PTGFRN-NOTCH2 transcript only includes a small portion of PTGFRN and the expression of PTGFRN and NOTCH2 are not down-regulated in CRC, we reason that the original functions of these two genes are not affected by this fusion event, and therefore, the gain of function of this fusion construct will be particularly interesting for future study.