MBNL1 and cancer: We checked the expression of the slicing factors derived from NCBI and SpliceAid 2 (http://www.introni.it/spliceaid.html), and found that four splicing factors, including RBFOX1, SPRK1, MBNL1 and SRRM2, were significantly dysregulated between the cancer tissue and non-cancer tissue (Table S1), suggesting that the anomalous splicing activity in cancer tissue might be related with the dysregulation of the splicing factors.