The result of the remained patients showed that, except for ITGB5, the other three genes COL1A1, FN1and SPP1were up-regulated in six cancer samples, and the COL3A1 was up-regulated in four cancer samples (Table S3), suggesting the ECM-pathway genes are usually up-regulated in colorectal cancer. This evidence concerns the gene MMRN1 and colorectal cancer.