A signature of genes including CDC20, CCNB1, CDC2, CDKN3, MAD2L1, PRC1 and RRM2, were prognostic for 5-year survival in over 400 lung cancer cases [101], and interestingly, CDC20, CDC2, CCNB1 were also highly overexpressed in the aggressive case. The gene discussed is POLD1; the disease is lung carcinoma.