BUB1 (9.6-fold) and BUB1B (5.7-fold) are involved in the spindle assembly checkpoint, and overexpression of BUB1B significantly correlated with higher histological grade, advanced pathological stage, and high cell proliferation in bladder cancer and predicted tumour recurrence and disease progression [92]. The gene discussed is BUB1B; the disease is urinary bladder carcinoma.