DNA damage response, repair, elongation and telomere extension, related directly and indirectly to platinum resistance were overexpressed, such as the CHEK2 gene, the CHK1 protein, the POLD1, POLA2, LIG3, FANCD2 and finally the novel DNA repair genes PRPF19 and RECQ5, not previously described in mesothelioma. This evidence concerns the gene PRPF19 and mesothelioma.