PDX1 and familial hyperinsulinism: Combined with the finding that 36 human pancreatic neuroendocrine tumors and nesidioblastosis specimens had marked overexpression of PDX-1, these data suggest that our novel RNAi effector platform has clinical potential for treating both the hormonal symptoms associated with excessive hormonal secretion, as well as control of tumor volume associated with pancreatic neuroendocrine tumors [38].