Three cycles of shRNAmousePDX-1 lipoplexes (35 ug/mouse) were well tolerated and significantly reversed basal hyperinsulinemia and hypoglycemia in SSTR1/5−/− mice (3±0.2 ug/l and 83±19.5 mg/dl on day 0 and 0.5±0.1 ug/l and 205±25.9 mg/dl on day 35 after three treatments, respectively, as seen in Fig. 5a and b); empty vector lipoplexes had no effect on hyperinsulinemia and hypoglycemia (Fig. 7a and b). Here, SSTR1 is linked to Hyperinsulinemia.