POU5F1 and central nervous system cancer: Low levels of Egln3 induction (0.25μg/mL Dox) reduced the transcription of Klf5 and the Hif-2α transcriptional target, Oct4 [18] by ≈50% and ≈70%, respectively within Hu-glioma cells relative to hypoxia-treated controls (Figure 5A).