In addition, quantification of total tumor Vegf, Klf5 and Oct4 transcript levels indicated that Egln3H196A induction did not inhibit Hif-mediated transcription whereas tumors expressing wild-type Egln3 displayed decreases in Vegf, Klf5 and Oct4 in vivo (Figure 7B). The gene discussed is EGLN3; the disease is neoplasm.