Given the known importance of integrin αvβ6 expression by lung epithelial cells in regulation of lung pathology during various pulmonary diseases (Sheppard 2004), and recent data suggesting an important role for integrin αvβ5-mediated TGFβ activation by airway smooth muscle cells in mediating pathology during asthma (Tatler et al. 2011), it appears that there are multiple integrin-mediated mechanisms to regulate TGFβ activity in the lung during disease. This evidence concerns the gene TGFB1 and lung disorder.