MYC and cancer: Our index study described a potent thienodiazepine inhibitor ((+)-JQ1; Figure 1B; Kd = 90 nM) of the BET family coactivator protein BRD4, which is implicated in the pathogenesis of cancer via transcriptional control of the MYC oncogene (Delmore et al., 2011; Zuber et al., 2011).