In translational models of solid and hematologic malignancies, the cancer-specific antiproliferative activity of JQ1 has been mechanistically linked to addiction to the BRD4 proto-oncogene (Filippakopoulos et al., 2010) or oncogenic MYC (a BRD4 target gene) (Delmore et al., 2011; Zuber et al., 2011). This evidence concerns the gene BRD4 and cancer.