In our study, pTyr1068 expression had a weak correlation with EGFR mutation and patients with pTyr1068 expression possessed a better response and prolonged PFS to EGFR-TKIs therapy, whereas pTyr1173 positive tumor was not correlated with EGFR mutation and had poor outcome to EGFR-TKIs therapy. This evidence concerns the gene EGFR and neoplasm.