TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: To the best of our knowledge, the present case is the only ever seen case of Ph chromosome-positive CML-CP with dic(17;18)(p13.1;q11.2), loss of TP53 gene, co-expression of b2a2 and b3a2 fusions transcript and T315I mutation resulting in Glivec resistance [14].