SKP2 and acute myeloid leukemia: Moreover, BM materials from 8 de novo AML patients, 8 patients in 1st CR and 5 healthy controls randomly chosen from our AML patient pool were used to determine the mRNA expression level of c-Myc, hTERT, p27kip1 and skp2, all of which were the target genes of FoxM1, using real-time PCR method.