Moreover, 15 of 22 genes that were reported to be overexpressed in PC were involved in cell metastasis, including ITGB4, ANG, VEGFA, S100A4, WNT5A, and TGFB2 as well as cell survival, such as BCL2, BIRC3, IGFBP6, KLF4, and PLAU. Here, BIRC3 is linked to pachyonychia congenita.