Moreover, 15 of 22 genes that were reported to be overexpressed in PC were involved in cell metastasis, including ITGB4, ANG, VEGFA, S100A4, WNT5A, and TGFB2 as well as cell survival, such as BCL2, BIRC3, IGFBP6, KLF4, and PLAU. The gene discussed is IGFBP6; the disease is pachyonychia congenita.