ATP7A and early-onset autosomal dominant Alzheimer disease: Notwithstanding the importance of ATP7A in these genetic disorders, numerous studies have also implicated ATP7A in a wide range of highly specialized processes beyond cellular copper homeostasis including glutamateric signaling and synaptogenesis in neurons [23], [24], macrophage bactericidal activity [25], oxidation of low density lipoprotein particles [26], smooth muscle migration [27], Alzheimer's disease [28], and multidrug resistance in cancer cells [29], [30].