VIM and scleroderma: Similar results were obtained in scleroderma fibroblasts (SCL) (Figure 1A, lower images), rat cardiac fibroblasts (RCF) (Figure 1B, upper images) and mouse embryonic fibroblasts (MEFs) (Figure 1B, lower images) suggesting that WF-A can disrupt vimentin filaments in fibroblasts of different sources.