To further evaluate the relationship between microRNA-126 and PIK3R2 in NSCLC, we detected the expression levels of microRNA-126, PIK3R2 and Akt phosphorylation in 381 clinical samples by quantitative real time PCR (qRT-PCR) and immunocytochemistry (IHC) respectively. Here, PIK3R2 is linked to non-small cell lung carcinoma.