Although a study identified that Ets-1 and Ets-2 can regulate the expression of microRNA-126 by targeting an Ets binding element in genomic regions upstream of the microRNA-126 and EGFL7 gene in endothelial cells [39], further studies are necessary to determine whether the above mechanism involves in the down-regulation of microRNA-126 in NSCLC. The gene discussed is EGFL7; the disease is non-small cell lung carcinoma.