In this study, we systematically evaluated the expression of Gal-3 in 120 paired human pancreatic tissues from normal pancreas, pancreatitis and pancreatic tumors, and for the first time determined the expression of Gal-3 in tissues and tumor cells derived from of a mutant K-Ras mouse model of pancreatic cancer. Here, KRAS is linked to familial pancreatic carcinoma.