Both the previously published therapeutic efficacy of chronic fluoxetine treatment in our mouse model of PTSD [30], its reported ability to induce synaptophysin expression in a mouse model of learned helplessness [38], and its reported efficacy in the treatment of PTSD in humans [31], motivated us to analyze whether this SSRI antidepressant is also able to rescue footshock-elicited hippocampal SV protein reduction. This evidence concerns the gene SYP and post-traumatic stress disorder.