PTEN and schizophrenia: In this regard, an argument could be made that Pten haplo-insufficient mice would serve as a better model for schizophrenia than autism given that (i) the atypical social behavior observed in this study was not observed until post adolescence when an autistic-like phenotype would require a model in which the behavioral and anatomical changes are present before adolescence (autism requires a diagnosis before 3 years of age [89], [90]) and (ii) mitochondrial dysfunction is present in individuals with schizophrenia [91].