Considering that disturbances in energy metabolism underlie some neurological conditions such as schizophrenia, affective disorders, fragile X-associated tremor and ataxia syndrome (FXTAS) and autism [32], [64]–[66], we tested if Pten haplo-insufficiency in neural tissues resulted in the occurrence of aberrant social and repetitive behavior and/or mitochondrial dysfunction, and evaluated the mechanism for such dysfunction. This evidence concerns the gene PTEN and schizophrenia.