KCNMA1 and Familial prostate cancer: We found that knockdown of KCNMA1 by siRNA and specific BK channel blockade by iberiotoxin inhibited cell proliferation of the prostate cancer cell line PC3, which carries an amplification of KCNMA1. This study suggested a specific role of KCNMA1 in the transition from hormone-sensitive to hormone-insensitive and castration-refractory prostate cancer [13].