Demanet et al. showed, in leukemic cells from 24 patients with acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), selective downregulation of HLA-A and HLA-Bw6 associated with HLA-Bw4 preservation, which provided an escape mechanism not only from T-cells but also from NK cell surveillance [14]. The gene discussed is HLA-A; the disease is acute lymphoblastic leukemia.