All three compounds were found to be cytotoxic and/or cytostatic on a range of FGFR3- or FGFR1-dependent bladder cancer cell lines in vitro and to reduce FGFR phosphorylation and downstream signalling, with PD173074 and TKI258 showing the greatest effect [89, 90]. The gene discussed is FGFR1; the disease is urinary bladder cancer.