APOE and Alzheimer disease: These include: nectin-2, also known as herpes virus entry-mediator-B or poliovirus receptor-related protein-2, which mediates the entry of HSV into host cells; apolipoprotein E (APOE), particularly its ε4 allele, which besides being a well-estabilished genetic risk factor for AD, has also been shown to influence susceptibility to viral infections and spreading into neuronal cells; translocase of the outer mitochondrial membrane 40 homolog (TOMM40), whose variations might influence mitochondrial damage induced by HSV DNAase such as UL12.5, and other genes.