APP and neuroblastoma: Other studies suggest that HSV-1 infection can interfere with APP processing: Shipley et al. [105] showed that HSV-1 infection of neuroblastoma cells induced the formation of a 55-kDa C-terminal fragment of APP; Wozniak et al. [104] found that BACE1 (β-secretase) and nicastrin (an essential component of the γ-secretase complex) immunolabeling is increased in the brains of HSV-1-infected mice.