Subsequently, HSV-1 infection in neuroblastoma and glioblastoma cells was shown to induce the phosphorylation of tau at a number of sites that were shown to be phosphorylated in AD, also demonstrating a consistent increase in the amount of the relevant enzymes, i.e. glycogen synthase kinase 3β and protein kinase A [110]. This evidence concerns the gene MAPT and Alzheimer disease.