MAPT and Alzheimer disease: A previous paper by Giunta et al. [121] reported an increased amyloid-β deposition and tau hyperphosphodrylation in a mouse model of HIV-1 Tat-induced AD-like pathology generated by crossing PSAPP (APPswe and PSEN1dE9) [122] and HIV-1 Tat transgenic mice [123] compared with PSAPP mice, indicating that the viral protein Tat significantly promotes an AD-like pathology in PSAPP/Tat mice.