Indeed, we observed a dose dependent relationship between the 148 M variant and adiponectin, which was evident in both in healthy controls and patients with NAFLD, but, due to the very well known gender-specific dimorphism of adiponectin levels which are higher in females [8], it more frequently contributed to hypo-adiponectinemia in females. Here, ADIPOQ is linked to metabolic dysfunction-associated steatotic liver disease.