In patients with histological NAFLD, PNPLA3 148 M alleles were associated with low adiponectin levels independently of age, sex, BMI, ADIPOQ genotype, and the severity (grade 1 to 3) of steatosis (OR 2.20, 95% c.i. 1.09-4.80; p = 0.027). The gene discussed is ADIPOQ; the disease is steatosis.