PNPLA3 and steatosis: On the other hand, despite in line with previous findings PNPLA3 genotype influenced steatosis in CHC and was possibly associated with lower triglycerides, in these patients PNPLA3 and ADIPOQ were not significantly associated with adiponectin, possibly due to development of adiponectin resistance associated with chronic HCV infection, in particular in patients with more severe disease [14].