Furthermore, although the association between PNPLA3 genotype and adiponectin was independent of steatosis severity in patients with NAFLD, our results does not exclude that PNPLA3 may modulate adipose tissue indirectly by regulating the secretion of hepatokines such as fetuin [40], and that it may also modulate other pro-inflammatory molecules such as resistin and ICAM-1 [26,41]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.