The I148M polymorphism of Patatin-like phospholipase domain-containing 3 (PNPLA3), influences hepatic triglycerides accumulation and the susceptibility to fibrotic NASH in adults and children [16-19], steatosis susceptibility and liver damage progression in CHC [19-22], and progression to hepatocellular carcinoma [21]. The gene discussed is PNPLA3; the disease is cryohydrocytosis.