APC and malignant colon neoplasm: In this study, we evaluated the cytotoxic activity of the extracts against three colon cancer cell lines with varying molecular characteristics, HT-29 (APC, type II truncation and COX-2 constitutive expression), HCT-15 (COX-2 deficient) and HCT 116 (APC, wild-type and COX-2 inducible) [14].