Using anti-UBQLN2 antibodies named 5F5 (Abnova, Walnut, CA, USA) and AP12092PU-N (Acris, San Diego, CA, USA), a recent study showed that numerous immunopositive aggregates and dystrophic neurites are accumulated in the hippocampal molecular layer and CA1-CA4 regions in the brains of FTLD/ALS patients with C9orf72 expansion, whereas the brains of the cases without the expansion barely show these structures [27]. This evidence concerns the gene UBQLN2 and amyotrophic lateral sclerosis.