TNF and metabolic syndrome: A curious result was observed at 3 month of age, when IL-6 was lower in MetS and H animals, as compared do C. CRP (Panel B) and TNF-alpha (Panel C) were also higher in MetS animals in all ages, as compared do C and H animals; indeed, these cytokines were elevated in H, as compared to C at all ages, except at 9 months for TNF-alpha.