Inflammatory cytokines produced by the adipose tissue, such as TNF-α (tumor necrosis factor-α) and interleukin-6 (IL-6) have been related to reduce GLUT4 expression [8,9], consequently lowering glucose uptake by muscle, and participating on the compensatory hyperinsulinemia [7,15,16]. The gene discussed is TNF; the disease is Hyperinsulinemia.