Without treatment the average survival in Sweden is 9–13 years after onset2,3 and death is caused by severe malnutrition and opportunistic infections in many cases.3,4 As nearly all circulating TTR is produced by the liver, a liver transplantation (Ltx) that ceases the synthesis of mutated TTR has proved to halt the progression of the disease. The gene discussed is TTR; the disease is nutritional deficiency disease.