ALOX15 and Familial prostate cancer: This new study demonstrates for the first time the overexpression of 12-LOX and the higher level of production of its AA metabolite 12-HETE (relative to its production in normal prostate tissues) in highly metastatic prostate cancer cells, at least PC-3 and MDA PCa 2b cells in vitro, as well as in corresponding xenografts and tissues from malignant human prostate tumors.