ALOX15 and Familial prostate cancer: Furthermore, other investigators have suggested that 12-LOX is related to the metastatic potential of prostate cancer since the expression of 12-LOX was higher in prostate cancer cell lines that metastasized in their corresponding xenograft models (e.g., DU145) than its expression was in PC-3 nm, a nonmetastatic subline of the PC-3 cell line (43).