We found that FH-autoantibodies present in aHUS/DEAP-HUS patients bound mainly to the C-terminus of FH as previously reported [17], since we detected the strongest signals of the three serum samples of aHUS patients for intact FH, CCPs 15 to 20 and CCPs 19 to 20 but very low level of interaction with FHL-1, which contains only CCP1 to 7 (Figure 2). Here, FHL1 is linked to hemolytic-uremic syndrome.