CD4 and HIV infectious disease: The correlation between time of HIV diagnosis and BMD in the femoral neck as well as nadir CD4+ T-cell count < 200 cells/μL and BMD in both the lumbar spine and femoral neck and the finding that nadir CD4+ T-cell count < 200 cells/μL was an independent predictor of low BMD, suggest that HIV infection per se and in particular the more advanced stages of the disease might affect the skeletal system.