HTT and Huntington disease: Prior in vitro observations, cell culture studies, and experiments in Drosophila have demonstrated that mutant htt can sequester normal htt in protein aggregates, but recent analyses of human postmortem brain extracts and protein extracts derived from HD mouse models using blue native polyacrylamide gel eletrophoresis (BNP) have shown that full-length normal and mutant htt are predominantly monomeric [33].