To explore the effect of expressing a version of htt with a normal human polyQ stretch and human PRR on HD mouse model phenotypes, we first compared the number of striatal neuropil and nuclear inclusions in Hdh140Q/3xFlag7Q and Hdh140Q/3xFlag20Q mice at 2 months, 4 months, 6 months, and 24 months of age (n=4 of each genotype) (Figure 6). Here, HTT is linked to Huntington disease.