Furthermore, HP negative status (as assessed by histology) was reported to be the most significant independent prognostic factor of poor OS (HR 3.45, 95% CI: 2.43-4.89, p < 0.0001) in a different study which included only patients with locally advanced gastric cancer who underwent adjuvant chemotherapy after curative resection (≥D2 dissection) [33]. The gene discussed is HP; the disease is gastric cancer.